Paydirt
SYRE
Ticker

Spyre Therapeutics, Inc.

SYRE · Healthcare · Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory…

Spyre Therapeutics, Inc. (SYRE), in the Healthcare sector, has 27 disclosed filings on Paydirt over the trailing twelve months from 7 corporate insiders: 0 purchases and 27 sales. Filers took a median of 2 days from execution to disclosure, and the most recent trade was executed Sep 2 and filed Sep 4. The most active filer was Cameron Turtle with 11 filings.

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Filings, ttm
27
0 buys · 27 sells
Traders, ttm
7
7 insiders
Volume, ttmiDollar value disclosed in the window
$436.0M
estimated for Congress, as filed for insiders
Median delay
2d
execution to disclosure
Last traded
Sep 2
Filed Sep 3
ADViAverage daily dollar volume
$134.1M
market data
Share price · 12M
$88.98 (+481.9%)
$109$62.10$15.29Sep 22 2025Mar 16Sep 4

Adjusted for splits and dividends.

Volume by month
$405.2M$202.6M$0Oct 2024Apr 2025Oct 2025Apr 2026Nov 2024 · sells $246KSep 2025 · sells $300KNov 2025 · sells $1.0MDec 2025 · sells $435KJan 2026 · sells $387KFeb 2026 · sells $462KMar 2026 · sells $633KApr 2026 · sells $1.4MMay 2026 · sells $13.4MJun 2026 · sells $405.2MJul 2026 · sells $2.7MAug 2026 · sells $4.5MSep 2026 · sells $5.9M
Buys $0 Sells $436.5M

Estimated for Congress, as filed for insiders · by filing month · past 24 months

Who filed
CT Cameron Turtle Chief Executive Officer 11 filings SB Scott L Burrows Chief Financial Officer 8 filings SS Sheldon Sloan Chief Medical Officer 4 filings JA Jeffrey W. Albers Director 2 filings MH Michael Thomas Henderson Director 2 filings FL Fairmount Funds Management LLC Director 1 filing HJ Heidy King-Jones See Remarks 1 filing
Recent filings
Heidy King-JonesSALE See Remarks $2.4M
27,599 sh across 3 lots
Exec Sep 1
Filed Sep 3 · 9:34 PM ET
Scott L BurrowsSALE Chief Financial Officer $2.2M
24,632 sh across 3 lots
Exec Sep 1
Filed Sep 3 · 9:33 PM ET
Cameron TurtleSALE Chief Executive Officer $1.3M
14,600 sh across 3 lots
Exec Sep 1
Filed Sep 3 · 9:33 PM ET
Jeffrey W. AlbersSALE Director $2.4M
23,000 sh across 3 lots
Exec Aug 7
Filed Aug 10 · 9:31 PM ET
Scott L BurrowsSALE Chief Financial Officer $707K
7,400 sh across 2 lots
Exec Aug 3
Filed Aug 5 · 9:32 PM ET
Cameron TurtleSALE Chief Executive Officer $1.4M
14,184 sh across 3 lots
Exec Aug 3
Filed Aug 5 · 9:31 PM ET
Scott L BurrowsSALE Chief Financial Officer $658K
7,500 sh across 2 lots
Exec Jul 1
Filed Jul 2 · 9:33 PM ET
Sheldon SloanSALE Chief Medical Officer $731K
8,334 sh across 2 lots
Exec Jul 1
Filed Jul 2 · 9:33 PM ET
Cameron TurtleSALE Chief Executive Officer $1.3M
14,410 sh across 2 lots
Exec Jul 1
Filed Jul 2 · 9:32 PM ET
Scott L BurrowsSALE Chief Financial Officer $1.3M
15,000 sh across 2 lots
Exec Jun 25
Filed Jun 26 · 5:30 PM ET
Michael Thomas HendersonSALE Director $2.0M
20,000 sh × $100.00
Exec Jun 22
Filed Jun 23 · 5:30 PM ET
Fairmount Funds Management LLCSALE Director $399.7M
4,684,781 sh × $85.31
Exec Jun 23
Filed Jun 23 · 5:30 PM ET
Scott L BurrowsSALE Chief Financial Officer $533K
7,500 sh across 3 lots
Exec Jun 1
Filed Jun 3 · 5:30 PM ET
Cameron TurtleSALE Chief Executive Officer $1.1M
15,000 sh across 3 lots
Exec Jun 1
Filed Jun 3 · 5:30 PM ET
Sheldon SloanSALE Chief Medical Officer $625K
8,333 sh × $75.00
Exec Jun 3
Filed Jun 3 · 5:30 PM ET
Michael Thomas HendersonSALE Director $6.0M
80,000 sh across 4 lots
Exec May 8
Filed May 8 · 5:30 PM ET
Cameron TurtleSALE Chief Executive Officer $976K
13,700 sh across 4 lots
Exec May 1
Filed May 1 · 5:30 PM ET
Sheldon SloanSALE Chief Medical Officer $5.6M
77,933 sh across 6 lots
Exec May 1
Filed May 1 · 5:30 PM ET
Scott L BurrowsSALE Chief Financial Officer $892K
12,500 sh × $71.37
Exec May 1
Filed May 1 · 5:30 PM ET
Scott L BurrowsSALE Chief Financial Officer $305K
6,200 sh × $49.21
Exec Apr 1
Filed Apr 3 · 5:30 PM ET
Sheldon SloanSALE Chief Medical Officer $398K
7,958 sh × $50.00
Exec Apr 1
Filed Apr 3 · 5:30 PM ET
Cameron TurtleSALE Chief Executive Officer $740K
15,000 sh across 2 lots
Exec Apr 1
Filed Apr 3 · 5:30 PM ET
Cameron TurtleSALE Chief Executive Officer $633K
15,000 sh across 2 lots
Exec Mar 2
Filed Mar 3 · 5:30 PM ET
Cameron TurtleSALE Chief Executive Officer $462K
14,043 sh × $32.87
Exec Feb 2
Filed Feb 4 · 5:30 PM ET
Cameron TurtleSALE Chief Executive Officer $387K
12,709 sh × $30.47
Exec Jan 2
Filed Jan 6 · 5:30 PM ET