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Baker Bros. Advisors Lp

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Baker Bros. Advisors Lp (Other) filed 10 Form 4 reports as a reporting entity in the trailing twelve months (9 purchases, 1 sale), most often in Kodiak Sciences Inc. (KOD). Across 7 priced purchase filings, the average 21-session return was +27.3% from execution and +5.7% from disclosure (delay-adjusted; derived). The largest single filing was $317.8M of CELC (3,100,000 sh across 2 lots, as filed), executed Jul 14. Data as of Nov 8 2026.

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Return, ttmiAverage return per filing, trailing twelve months
+27.3%
avg across 7 priced filings
Delay-adjustediThe same average, entered at disclosure dates
+5.7%
same 7 filings, from disclosure
Filings, ttm
10
9 buys · 1 sells
Median delay
2d
execution → disclosure
Volume, ttmiDollar value disclosed in the trailing twelve months
$765.6M
shares × price, as filed
Last traded
Nov 6
Filed Nov 6

Median ADV $129.9M across their filed names

Impact on $10,000 · 12M
$12,735 (+27.4%)
S&P 500 $10,907 (+9.1%) · 18.3 pts ahead
$14.5k$11.9k$9.3kNov 10 2025May 12Nov 6
Baker Bros. Advisors Lp S&P 500

Derived: compounded across filings from disclosure dates · past 12 months

Open performance→
Volume by month
$317.8M$158.9M$0Dec 2024Jun 2025Dec 2025Jun 2026Aug 2025 · buys $61.2MSep 2025 · buys $9.5MNov 2025 · buys $1.3MDec 2025 · buys $232.5MJul 2026 · sells $317.8MSep 2026 · buys $156.0MNov 2026 · buys $59.4M
Buys $519.9M Sells $317.8M

Shares × price, as filed · by filing month · past 24 months

Sectors filed on
Healthcare 10 filings

Sector per market data · by filing · past 12 months

Most traded names
KOD Kodiak Sciences Inc. KOD · 5 buys · 0 sells 5 filings MDGL Madrigal Pharmaceuticals, Inc. MDGL · 3 buys · 0 sells 3 filings CELC Celcuity Inc. CELC · 1 buy · 1 sell 2 filings TRDA Entrada Therapeutics, Inc. TRDA · 2 buys · 0 sells 2 filings KYMR Kymera Therapeutics, Inc. KYMR · 1 buy · 0 sells 1 filing
Recent filings
TRDAPURCHASE Entrada Therapeutics, Inc. View filing → $240K
26,468 sh across 2 lots
Exec Nov 20 2025
Filed Nov 24 2025 · 4:09 PM ET
TRDAPURCHASE Entrada Therapeutics, Inc. View filing → $1.0M
137,124 sh across 3 lots
Exec Nov 10 2025
Filed Nov 12 2025 · 5:34 PM ET
CELCPURCHASE Celcuity Inc. View filing → $9.5M
169,712 sh across 3 lots
Exec Sep 8 2025
Filed Sep 10 2025 · 4:06 PM ET
MDGLPURCHASE Madrigal Pharmaceuticals, Inc. View filing → $36.7M
96,519 sh across 22 lots
Exec Aug 18 2025
Filed Aug 20 2025 · 6:12 PM ET
MDGLPURCHASE Madrigal Pharmaceuticals, Inc. View filing → $24.5M
67,279 sh across 21 lots
Exec Aug 18 2025
Filed Aug 20 2025 · 6:09 PM ET