Orbimed Advisors Llc

Director

Orbimed Advisors Llc (Director) filed 18 Form 4 reports as a reporting entity in the trailing twelve months (10 purchases, 8 sales, 1 filed past the two-business-day deadline), most often in Sionna Therapeutics, Inc. (SION). Across 8 priced purchase filings, the average 21-session return was +11.7% from execution and +14.6% from disclosure (delay-adjusted; derived). The largest single filing was $38.9M of ELVN (858,646 sh across 3 lots, as filed), executed Jun 22. Data as of Nov 8 2026.

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Return, ttmiAverage return per filing, trailing twelve months

+11.7%

avg across 8 priced filings

Delay-adjustediThe same average, entered at disclosure dates

+14.6%

same 8 filings, from disclosure

Filings, ttm

10 buys · 8 sells · 1 late

Median delay

execution → disclosure

Volume, ttmiDollar value disclosed in the trailing twelve months

$242.6M

shares × price, as filed

Last traded

Nov 5

Filed Nov 5

Median ADV $26.9M across their filed names

Impact on $10,000 · 12M

$17,583 (+75.8%)

S&P 500 $10,907 (+9.1%) · 66.8 pts ahead

Orbimed Advisors Llc S&P 500

Derived: compounded across filings from disclosure dates · past 12 months

Open performance→

Volume by month

Buys $153.5M Sells $113.0M

Shares × price, as filed · by filing month · past 24 months

Sectors filed on

Healthcare 16 filings Not on file 2 filings

Sector per market data · by filing · past 12 months

Most traded names

SION

Sionna Therapeutics, Inc. SION · 0 buys · 6 sells 6 filings ELVN

Enliven Therapeutics, Inc. ELVN · 0 buys · 2 sells 2 filings ETRA

Electra Therapeutics, Inc. ETRA · 2 buys · 0 sells 2 filings ACET ACET 1 buy · 0 sells 1 filing ADRX

ADARx Pharmaceuticals, Inc. ADRX · 1 buy · 0 sells 1 filing

Recent filings

SIONSALE Sionna Therapeutics, Inc. View filing → $22.9M
510,583 sh across 3 lots
Exec Apr 14
Filed Apr 16 · 5:30 PM ET SIONSALE Sionna Therapeutics, Inc. View filing → $4.7M
106,473 sh across 2 lots
Exec Nov 24 2025
Filed Nov 26 2025 · 5:30 PM ET ACETPURCHASE Adicet Bio, Inc. View filing → $5.0M
5,000,000 sh across 2 lots
Exec Oct 8 2025
Filed Oct 10 2025 · 8:06 PM ET PMVPSALE PMV Pharmaceuticals, Inc. View filing → $900K
500,000 sh × $1.80
Exec Sep 10 2025
Filed Sep 12 2025 · 5:30 PM ET STTKPURCHASE Shattuck Labs, Inc. View filing → $5.5M
6,306,127 sh across 2 lots
Exec Aug 25 2025
Filed Sep 2 2025 · 9:52 PM ET † CRVSSALE Corvus Pharmaceuticals, Inc. View filing → $4.9M
1,176,332 sh × $4.16
Exec Jun 27 2025
Filed Jul 1 2025 · 5:30 PM ET NPCESALE NeuroPace Inc View filing → $2.7M
168,136 sh across 2 lots
Exec May 14 2025
Filed May 16 2025 · 5:30 PM ET IRONSALE Disc Medicine, Inc. View filing → $270K
4,982 sh across 2 lots
Exec Mar 24 2025
Filed Mar 26 2025 · 5:30 PM ET