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Opaleye Management Inc.

10% owner

Opaleye Management Inc. (10% owner) filed 36 Form 4 reports as a reporting entity in the trailing twelve months (22 purchases, 14 sales, 3 filed past the two-business-day deadline), most often in CDXS. Across 18 priced purchase filings, the average 21-session return was +19.2% from execution and +19.4% from disclosure (delay-adjusted; derived). The largest single filing was $7.8M of HROW (197,263 sh across 3 lots, as filed), executed Mar 3.

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Return, ttmiAverage return per filing, trailing twelve months
+19.2%
avg across 18 priced filings
Delay-adjustediThe same average, entered at disclosure dates
+19.4%
same 18 filings, from disclosure
Filings, ttm
36
22 buys · 14 sells · 3 late
Median delay
2d
execution → disclosure
Volume, ttmiDollar value disclosed in the trailing twelve months
$39.4M
shares × price, as filed
Last traded
Sep 16
Filed Sep 16

Median ADV $2.8M across their filed names

Impact on $10,000 · 12M
$34,347 (+243.5%)
S&P 500 $11,725 (+17.2%) · 226.2 pts ahead
$36.5k$23.0k$9.5kSep 22 2025Mar 23Sep 21
Opaleye Management Inc. S&P 500

Compounded across filings from disclosure dates · past 12 months

Open performance
Volume by month
$8.1M$4.0M$0Oct 2024Apr 2025Oct 2025Apr 2026Oct 2024 · buys $312KNov 2024 · buys $243KJan 2025 · buys $358KJan 2025 · sells $712KMar 2025 · buys $1.4MMar 2025 · sells $438KApr 2025 · buys $647KMay 2025 · buys $5.5MMay 2025 · sells $690KJun 2025 · buys $560KJun 2025 · sells $924KJul 2025 · buys $521KAug 2025 · buys $226KNov 2025 · buys $207KNov 2025 · sells $1.6MDec 2025 · buys $3.1MDec 2025 · sells $3.3MJan 2026 · buys $223KJan 2026 · sells $1.1MFeb 2026 · buys $875KMar 2026 · buys $3.6MMar 2026 · sells $8.1MApr 2026 · sells $1.5MMay 2026 · buys $749KMay 2026 · sells $550KJun 2026 · buys $1.1MJul 2026 · buys $1.6MJul 2026 · sells $6.9MAug 2026 · buys $3.2MSep 2026 · buys $1.7M
Buys $26.1M Sells $25.8M

Shares × price, as filed · by filing month · past 24 months

Sectors filed on
Healthcare 28 filings Not on file 8 filings

Sector per market data · by filing · past 12 months

Most traded names
CDXS CDXS CDXS · 17 buys · 5 sells 22 filings SLGL Sol-Gel Technologies Ltd. SLGL · 13 buys · 0 sells 13 filings HROW Harrow, Inc. HROW · 0 buys · 11 sells 11 filings ACOG Alpha Cognition Inc. Common Stock ACOG · 9 buys · 0 sells 9 filings ETON Eton Pharmaceuticals, Inc. ETON · 1 buy · 3 sells 4 filings
Recent filings
ACOGPURCHASE Alpha Cognition Inc. Common Stock View filing → $1.0M
120,543 sh across 3 lots
Exec Sep 14
Filed Sep 16 · 5:57 PM ET
SLGLPURCHASE Sol-Gel Technologies Ltd. View filing → $109K
1,631 sh × $66.80
Exec Sep 10
Filed Sep 14 · 5:23 PM ET
SLGLPURCHASE Sol-Gel Technologies Ltd. View filing → $591K
8,587 sh across 3 lots
Exec Sep 4
Filed Sep 9 · 7:18 PM ET
SLGLPURCHASE Sol-Gel Technologies Ltd. View filing → $2.8M
40,113 sh across 4 lots
Exec Aug 28
Filed Aug 31 · 6:24 PM ET
ACOGPURCHASE Alpha Cognition Inc. Common Stock View filing → $400K
50,000 sh × $8.00
Exec Aug 3
Filed Aug 4 · 4:50 PM ET
ACOGPURCHASE Alpha Cognition Inc. Common Stock View filing → $1.5M
190,086 sh across 2 lots
Exec Jul 22
Filed Jul 24 · 4:05 PM ET
ETONSALE Eton Pharmaceuticals, Inc. View filing → $1.1M
28,315 sh across 2 lots
Exec Jul 14
Filed Jul 17 · 7:12 PM ET †
ETONSALE Eton Pharmaceuticals, Inc. View filing → $1.1M
28,315 sh across 2 lots
Exec Jul 14
Filed Jul 16 · 5:14 PM ET
More filings →