OI
Insider
Opaleye Management Inc.
10% ownerOpaleye Management Inc. (10% owner) filed 41 Form 4 reports as a reporting entity in the trailing twelve months (27 purchases, 14 sales, 3 filed past the two-business-day deadline), most often in CDXS. Across 24 priced purchase filings, the average 21-session return was +14.8% from execution and +15.1% from disclosure (delay-adjusted; derived). The largest single filing was $7.8M of HROW (197,263 sh across 3 lots, as filed), executed Mar 3. Data as of Nov 8 2026.
Add to watchlistReturn, ttmiAverage return per filing, trailing twelve months
+14.8%
avg across 24 priced filings
Delay-adjustediThe same average, entered at disclosure dates
+15.1%
same 24 filings, from disclosure
Filings, ttm
41
27 buys · 14 sells · 3 late
Median delay
2d
execution → disclosure
Volume, ttmiDollar value disclosed in the trailing twelve months
$38.6M
shares × price, as filed
Last traded
Oct 26
Filed Oct 26
Median ADV $2.8M across their filed names
Impact on $10,000 · 12M
$34,348 (+243.5%)
S&P 500 $10,907 (+9.1%) · 234.4 pts ahead
Opaleye Management Inc.
S&P 500
Derived: compounded across filings from disclosure dates · past 12 months
Open performance→Volume by month
Buys $26.7M
Sells $25.8M
Shares × price, as filed · by filing month · past 24 months
Sectors filed on
Healthcare
33 filings
Not on file
7 filings
Sector per market data · by filing · past 12 months
Most traded names
CDXS
CDXS
15 buys · 5 sells
20 filings
ACOGRecent filings
SLGLPURCHASE
Sol-Gel Technologies Ltd.
View filing →
$2.8M40,113 sh across 4 lots
Exec Aug 28
Filed Aug 31 · 6:24 PM ET ACOGPURCHASE Alpha Cognition Inc. Common Stock View filing → $400K
50,000 sh × $8.00
Exec Aug 3
Filed Aug 4 · 4:50 PM ET ACOGPURCHASE Alpha Cognition Inc. Common Stock View filing → $1.5M
190,086 sh across 2 lots
Exec Jul 22
Filed Jul 24 · 4:05 PM ET ETONSALE Eton Pharmaceuticals, Inc. View filing → $1.1M
28,315 sh across 2 lots
Exec Jul 14
Filed Jul 17 · 7:12 PM ET † ETONSALE Eton Pharmaceuticals, Inc. View filing → $1.1M
28,315 sh across 2 lots
Exec Jul 14
Filed Jul 16 · 5:14 PM ET ETONSALE Eton Pharmaceuticals, Inc. View filing → $4.8M
126,685 sh across 5 lots
Exec Jul 2
Filed Jul 7 · 6:29 PM ET SLGLPURCHASE Sol-Gel Technologies Ltd. View filing → $101K
1,400 sh × $71.97
Exec Jul 2
Filed Jul 2 · 6:11 PM ET ACOGPURCHASE Alpha Cognition Inc. Common Stock View filing → $975K
152,336 sh × $6.40
Exec Jun 26
Filed Jun 29 · 4:05 PM ET More filings →