OI
Insider
Opaleye Management Inc.
10% ownerOpaleye Management Inc. (10% owner) filed 41 Form 4 reports as a reporting entity in the trailing twelve months (27 purchases, 14 sales, 3 filed past the two-business-day deadline), most often in CDXS. Across 24 priced purchase filings, the average 21-session return was +14.8% from execution and +15.1% from disclosure (delay-adjusted; derived). The largest single filing was $7.8M of HROW (197,263 sh across 3 lots, as filed), executed Mar 3. Data as of Nov 8 2026.
Add to watchlistReturn, ttmiAverage return per filing, trailing twelve months
+14.8%
avg across 24 priced filings
Delay-adjustediThe same average, entered at disclosure dates
+15.1%
same 24 filings, from disclosure
Filings, ttm
41
27 buys · 14 sells · 3 late
Median delay
2d
execution → disclosure
Volume, ttmiDollar value disclosed in the trailing twelve months
$38.6M
shares × price, as filed
Last traded
Oct 26
Filed Oct 26
Median ADV $2.8M across their filed names
Impact on $10,000 · 12M
$34,348 (+243.5%)
S&P 500 $10,907 (+9.1%) · 234.4 pts ahead
Opaleye Management Inc.
S&P 500
Derived: compounded across filings from disclosure dates · past 12 months
Open performance→Volume by month
Buys $26.7M
Sells $25.8M
Shares × price, as filed · by filing month · past 24 months
Sectors filed on
Healthcare
33 filings
Not on file
7 filings
Sector per market data · by filing · past 12 months
Most traded names
CDXS
CDXS
15 buys · 5 sells
20 filings
ACOGRecent filings
ACOGPURCHASE
Alpha Cognition Inc. Common Stock
View filing →
$149K24,856 sh × $5.98
Exec Jun 9
Filed Jun 11 · 4:05 PM ET ACOGPURCHASE Alpha Cognition Inc. Common Stock View filing → $416K
70,577 sh × $5.90
Exec May 29
Filed May 29 · 7:21 PM ET SLGLPURCHASE Sol-Gel Technologies Ltd. View filing → $101K
1,563 sh × $64.43
Exec May 20
Filed May 22 · 4:05 PM ET SLGLPURCHASE Sol-Gel Technologies Ltd. View filing → $232K
3,437 sh across 2 lots
Exec May 12
Filed May 14 · 4:05 PM ET SNWVSALE SANUWAVE Health, Inc. View filing → $550K
34,081 sh across 2 lots
Exec Apr 30
Filed May 4 · 5:30 PM ET SNWVSALE SANUWAVE Health, Inc. View filing → $1.2M
67,148 sh across 2 lots
Exec Apr 28
Filed Apr 30 · 5:30 PM ET SNWVSALE SANUWAVE Health, Inc. View filing → $333K
16,267 sh across 2 lots
Exec Apr 17
Filed Apr 21 · 5:30 PM ET SLGLPURCHASE Sol-Gel Technologies Ltd. View filing → $2.9M
39,665 sh across 2 lots
Exec Mar 24
Filed Mar 24 · 4:05 PM ET More filings →